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Alexander MacInnis's avatar

Yes to:

1. The evidence clearly shows a very large rate of increase in the rate of occurrence of autism, not an artifact of something else.

2. The popular media, science journalism and peer-reviewed science journals all generally pretend that #1 is not true, without evidence. That is a serious problem that is impeding much-needed progress. The real reasons for that denial are largely hidden.

3. We must get serious about finding treatments and preventable causes of the worst symptoms.

4. We should absolutely be studying gene-environment (GxE) interactions in autism etiology. It's obvious that GxE is a dominant factor.

Note: Heritability from twin studies does not mean inherited.

But is "precision toxicology" the same thing as GxE?

Here's a paper that explains The Precision Toxicology initiative:

https://www.sciencedirect.com/science/article/abs/pii/S0378427423001807

The paper says that the basic approach is to find other animals with similar biological pathways to those in humans, plus isolated human cells, and do toxicology testing on them. Part of that involves looking at genetic susceptibility to toxins, which is effectively is GxE analysis.

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Eric D's avatar

This is great, Jill. MAHA can be dizzying, but like in Hollywood, bad press can still be good press.

I want the attention to find answers, but I also want that to translate into a) real dollars funding research and b) honest media brokers staying focused on the goal of getting those answers and less on whatever RFK says to confuse people about autism causation.

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